Follows the lives of a group of vampire roommates living on Staten Island.

When a freak virus kills all but four passengers on an airplane at JFK, Ephraim Goodweather, head of the Center for Disease Control's "Canary Team," is immediately called to the scene. With help from a mysterious Holocaust survivor, "Eph" and his colleague uncover the outbreak's ties to vampirism. Now, the only way to stop the terrifying disease from wiping out mankind is to face its source, a sinister supernatural creature known as "The Master."....

Follows the adventures of a young woman with supernatural abilities who strives to defeat Charlie Manx, an immortal who feeds on the souls of children and holds them in a place known as Christmasland.

The continuing adventures of vampire roommates Nandor, Nadja, Laszlo and Colin Robinson and their human familiar Guillermo as they further explore the human world of Staten Island, New York.

In the final ten episodes of this terrifying series from the visionary minds of Guillermo Del Toro, Carlton Cuse and Chuck Hogan, nuclear winter envelopes the planet, and a desperate, weakened humanity, existing only as slave labor for 'The Partnership', is controlled by the bloodthirsty strigoi. Meanwhile, the sinister 'Master' grooms Eph's son Zach to rule the post-apocalyptic dystopia.

Matthew and Diana return from their trip to 1590 to find tragedy has occurred at Sept-Tours. They are closer to knowing the location of the Book of Life and its missing pages, but enemies from their past and present are threatening from all sides.