Despite his overwhelming fear of interacting with people, Christopher, a mathematically-gifted, autistic fifteen-year-old boy, decides to investigate the murder of a neighbor's dog and uncovers secret information about his mother. Christopher John Francis Boone knows all the countries of the world and their capitals and every prime number up to 7,057. He relates well to animals but has no understanding of human emotions. He cannot stand to be touched....

The show is about a young surgeon with autism who is recruited to work at a pediatric unit of a hospital. The hospital is prestigious with many of the toughest cases a surgeon could ever see, but with autism comes clarity that most surgeons will never have. The television series focuses on the relationship between the doctor and patient, and how a man who cannot relate to the people who he tries to help.

"Set in the Carolinas in the 1940s, a young woman reckons not just with the unforgiving landscape, but with the rocky emotional terrain that leads from innocence to wisdom as jealousy and betrayal threaten to accomplish what hardship never could--divide the family for good"--